Overdiagnosis in histology can occur through several mechanisms, including: 1. Screening Programs: Widespread screening for cancers such as prostate, breast, and thyroid can lead to the identification of indolent or slow-growing tumors that may never cause clinical problems. 2. Improved Diagnostic Tools: High-resolution imaging and more sensitive molecular techniques can detect minute abnormalities, some of which may not be clinically relevant. 3. Pathologist Variability: Differences in interpretation among pathologists can lead to varying diagnoses for the same tissue sample, contributing to overdiagnosis.
