Alterations in microarchitecture can indicate various diseases. For instance:
Cancer: Tumors often show disrupted microarchitecture with irregular cell shapes, sizes, and loss of normal tissue organization. Chronic obstructive pulmonary disease (COPD): Characterized by destruction of alveolar walls, resulting in enlarged air spaces and reduced surface area for gas exchange. Liver cirrhosis: Demonstrates fibrosis and formation of regenerative nodules, altering normal lobular architecture.
