In the liver, the excessive glycogen storage leads to hepatomegaly, which can be observed histologically as enlarged hepatocytes filled with glycogen. Over time, chronic liver injury may result in fibrosis and cirrhosis. The liver architecture may be disrupted, and inflammatory infiltrates can be present. The glycogen-filled vacuoles within the hepatocytes can push the nucleus to the periphery, creating a characteristic sign known as the “plant cell” appearance.
