The effect of gene dosage on cellular function is largely dependent on the gene involved and the tissue type. For instance, an increase in gene dosage (gene duplication) can lead to overexpression of a protein, potentially causing cellular dysfunction or disease. Conversely, a decrease in gene dosage (gene deletion) can result in insufficient protein production, impairing cellular activities. This is particularly critical in tissues with high cellular turnover or specialized functions, such as the liver or nervous system.
