How Does Clostridium Perfringens Cause Tissue Damage?
Clostridium perfringens causes tissue damage through the production of several potent toxins, including alpha-toxin (phospholipase C) and theta-toxin (perfringolysin O). These toxins disrupt cell membranes, leading to cell lysis and tissue necrosis. Additionally, the bacteria produce collagenase and hyaluronidase, enzymes that degrade connective tissue and facilitate the spread of the infection.
