How Does Calcium Signaling Affect Neuronal Function?
In neurons, calcium signaling is essential for neurotransmitter release. When an action potential reaches the synaptic terminal, voltage-gated calcium channels open, allowing Ca2+ to enter the cell. The influx of calcium triggers the fusion of neurotransmitter-containing vesicles with the presynaptic membrane, releasing neurotransmitters into the synaptic cleft.