Reduction in collagen: The synthesis of collagen decreases, leading to thinner and less resilient skin. Loss of elastin: The degradation of elastin fibers results in reduced skin elasticity and the development of wrinkles. Decreased ground substance: The ground substance becomes less hydrated, leading to a loss of skin firmness and pliability. Vascular changes: Reduced blood flow affects nutrient delivery and waste removal, impairing skin health.