How do Vitamin B12 and Folate Deficiencies Affect Histology?
Deficiencies in vitamin B12 and folate can lead to significant histological changes, particularly in rapidly dividing cells. In the context of the bone marrow, deficiencies can cause megaloblastic anemia, characterized by the presence of abnormally large red blood cells known as megaloblasts. These cells exhibit irregular nuclear development due to impaired DNA synthesis.
