The process begins with the collection of tissue samples, which are then fixed, typically in formalin, to preserve their structure. The samples are then embedded in paraffin wax, sectioned into thin slices using a microtome, and stained with various dyes to highlight different cellular components. One common staining technique is the Hematoxylin and Eosin (H&E) stain, which provides a general overview of tissue architecture. Special stains and immunohistochemistry may be used to identify specific markers or pathogens.