How Do Histone Modifications Affect Gene Expression?
Histone modifications can either promote or inhibit gene expression by altering the chromatin structure. For example, histone acetylation typically leads to a more relaxed chromatin structure, thereby facilitating transcription. Conversely, histone methylation can either condense chromatin and repress transcription or relax chromatin and promote transcription, depending on the specific residues that are methylated.
