How Do Histological Stains Differ in Their Specificity and Sensitivity?
Different histological stains offer varying levels of specificity and sensitivity: - GMS Stain: Highly sensitive for detecting fungal cell walls but not specific to any particular species. - PAS Stain: Less sensitive than GMS but still effective for visualizing fungal elements. - Calcofluor White: A fluorescent stain that binds to cellulose and chitin in fungal cell walls, useful for rapid diagnosis.