How do Gliotransmitters Affect Neuronal Communication?
Gliotransmitters affect neuronal communication by engaging in a bidirectional interaction with neurons. This process is often referred to as the "tripartite synapse," where astrocytes, pre-synaptic neurons, and post-synaptic neurons interact closely. For example, D-serine, a gliotransmitter, co-agonizes with glutamate at NMDA receptors, which are critical for synaptic plasticity and memory formation.
