How Do Genetic Syndromes Affect Histological Features?
Genetic syndromes can affect the structure, function, and organization of tissues. For example, in Marfan Syndrome, a defect in the fibrillin-1 gene leads to abnormalities in connective tissue. Histologically, this can manifest as fragmented elastic fibers in the aorta. Similarly, in Ehlers-Danlos Syndrome, defects in collagen synthesis or structure can result in hyperelastic skin and fragile blood vessels.
