How do genetic factors influence histological changes?
Genetic predisposition plays a significant role in the development of OCD and related disorders. Mutations and polymorphisms in genes related to neurotransmitter systems, synaptic functioning, and neurodevelopment can lead to histological abnormalities. For example, variations in the SLC1A1 gene, which encodes a glutamate transporter, have been linked to OCD and exhibit changes in glutamatergic signaling pathways in the brain.
