How Do Genetic and Epigenetic Changes Drive Tumor Progression?
Genetic mutations and epigenetic modifications play critical roles in tumor progression. Mutations in oncogenes and tumor suppressor genes can lead to uncontrolled cell growth and survival. Epigenetic changes, such as DNA methylation and histone modification, can alter gene expression without changing the DNA sequence. These changes can be detected histologically by using techniques like immunohistochemistry and in situ hybridization.
