How do Crystallins Contribute to Cataract Formation?
Cataract formation is often linked to the aggregation and denaturation of crystalline proteins. As individuals age, post-translational modifications, such as phosphorylation and glycation, can alter the structure of crystallins. These modifications can reduce the proteins' solubility and chaperone activity, leading to protein aggregation and light scattering, ultimately resulting in cataracts.
