How do BRCA1 and BRCA2 Mutations Influence Tissue Pathology?
Mutations in BRCA1 and BRCA2 disrupt normal cell cycle control and DNA repair mechanisms. This disruption leads to an accumulation of genetic errors, which can manifest as morphological changes in tissues. For example, breast tissues from BRCA1 or BRCA2 mutation carriers often show increased ductal and lobular atypia, which are precursors to invasive cancer.
