How Can Genetic Mutations Affect Histological Observations?
Genetic mutations can significantly impact histological observations. For example, mutations in the BRCA1/BRCA2 genes are associated with an increased risk of breast and ovarian cancers. Histological examination of tissues from patients with these mutations often reveals distinct patterns of cellular abnormalities, such as increased mitotic activity and nuclear atypia, which are indicative of malignancy.
