How Can Covalent Modifications be Targeted Therapeutically?
Targeting covalent modifications has therapeutic potential. Inhibitors of kinases or phosphatases can modulate phosphorylation states, offering treatment options for diseases like cancer and diabetes. Epigenetic drugs that inhibit histone deacetylases (HDACs) or DNA methyltransferases (DNMTs) are being developed to reactivate silenced genes in cancer therapy.