Preventing autolytic changes is crucial for maintaining the integrity of histological samples. Key strategies include:
- Rapid Fixation: Fixatives such as formalin are used to preserve tissues immediately after removal. Fixation stabilizes cellular structures and inhibits enzymatic activity. - Temperature Control: Keeping tissues at low temperatures can slow down enzymatic processes and bacterial growth. - Proper Handling: Minimizing the time between tissue removal and fixation helps reduce the risk of autolysis.
