The synthesis of thromboxanes begins with the release of arachidonic acid from the phospholipid membrane of cells. This process is catalyzed by the enzyme phospholipase A2. Arachidonic acid is then converted into prostaglandin H2 (PGH2) by the enzyme cyclooxygenase (COX). Finally, thromboxane synthase catalyzes the conversion of PGH2 into thromboxane A2 (TXA2).
