Several techniques are employed to study these genes within the context of histology:
1. Immunohistochemistry (IHC): This technique uses antibodies to detect the presence and distribution of proteins encoded by these genes in tissue sections. 2. In Situ Hybridization (ISH): ISH can be used to localize specific mRNA transcripts within tissues, providing information on gene expression patterns. 3. Electron Microscopy: This can reveal ultrastructural details of mitochondria, helping to identify morphological changes associated with gene mutations. 4. PCR and Sequencing: These molecular techniques can be used to identify mutations in mtDNA extracted from tissue samples.
