How are Synapses Identified in Histological Studies?
Synapses can be identified through various histological techniques. Electron microscopy is often used to visualize synaptic structures at an ultrastructural level, revealing detailed images of synaptic vesicles, synaptic clefts, and post-synaptic densities. Immunohistochemistry can also be employed to label specific synaptic proteins, such as synaptophysin or PSD-95, using antibodies, thereby highlighting synaptic sites.
