In histology, non-caseating granulomas are identified through tissue biopsies stained with hematoxylin and eosin (H&E). Under the microscope, these granulomas appear as well-defined aggregates of epithelioid cells without the central necrosis seen in caseating granulomas. Special stains such as Ziehl-Neelsen and periodic acid–Schiff (PAS) may be used to rule out infections and other causes.
