The polymerization and depolymerization of microfilaments are tightly regulated by various actin-binding proteins (ABPs). These proteins include:
Thymosin and Profilin which regulate actin monomer availability. Capping Proteins that bind to the ends of actin filaments to prevent further polymerization or depolymerization. Severing Proteins such as gelsolin that cut actin filaments into shorter fragments. Crosslinking Proteins like filamin that organize actin filaments into networks.
