To study CNVs in histological samples, researchers often use techniques such as fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). FISH can be used to visualize specific DNA sequences within tissue sections, allowing for the detection of CNVs at a cellular level. IHC can be used to assess the expression of proteins encoded by genes affected by CNVs, providing insights into the functional consequences of these variations.
