How are Bleeding Disorders Diagnosed Histologically?

The diagnosis of bleeding disorders through histology involves several techniques:

Biopsy: A tissue biopsy can reveal structural abnormalities in blood vessels or tissues affected by bleeding.
Blood Smears: Examining blood smears under a microscope can identify abnormal platelet shapes, sizes, and counts.
Immunohistochemistry: This technique uses antibodies to detect specific clotting factors or platelet proteins in tissue samples.
Electron Microscopy: Provides detailed images of platelets and vascular structures to identify ultrastructural defects.