Diagnosis typically involves a combination of clinical evaluation, laboratory tests, and histological examination:
Peripheral blood smear: This can show spherocytes, schistocytes, or other abnormal RBC morphologies. Direct antiglobulin test (DAT): This detects antibodies or complement on the RBC membrane, indicating immune-mediated hemolysis. Histopathology: Examination of splenic or hepatic tissue may reveal increased macrophage activity and hemosiderin deposits.
