How Are Biomaterials Evaluated for Biocompatibility?
Biocompatibility evaluation involves both in vitro and in vivo testing. In vitro tests include cytotoxicity assays, where the material's effect on cell viability is assessed, and cell adhesion studies to evaluate how well cells attach and proliferate on the material's surface. In vivo tests involve implanting the material into an animal model and using histological techniques to examine tissue responses. Parameters such as fibrosis, angiogenesis, and immune cell infiltration are commonly assessed to determine biocompatibility.
