Creating annotated slides involves several steps: 1. Preparation of the Tissue Sample: The tissue is fixed, embedded, and sectioned into thin slices. 2. Staining: The sections are stained using specific dyes to highlight different cellular components. 3. Microscopy: The stained sections are examined under a microscope. 4. Annotation: Using software tools, labels, arrows, and notes are added to the digital image of the slide.