Can the Helix Turn Helix Motif Be Linked to Diseases?
Yes, mutations or malfunctions in proteins containing the hth motif can lead to various diseases. For instance, improper functioning of hth-containing proteins in epithelial cells can result in cancers or other disorders due to the misregulation of genes that control cell growth and division. Understanding these proteins and their DNA-binding capabilities can lead to better diagnostic and therapeutic strategies.
