Are there therapeutic interventions targeting CFTR?
Yes, recent advances have led to the development of CFTR modulators, which are drugs designed to correct the malfunctioning protein. These include potentiators that enhance the function of defective CFTR at the cell surface, and correctors that assist in proper folding and trafficking of CFTR to the membrane. Examples include ivacaftor, lumacaftor, and tezacaftor.
