Are There Any Limitations in Using Synaptophysin as a Marker?
While synaptophysin is a valuable marker, it is not without limitations. It is not exclusively specific to neuronal tissues and can be expressed in various other cell types, potentially leading to false positives. Moreover, its expression levels can vary between different types of neurons and tumors, which may complicate the interpretation of results. Therefore, synaptophysin is often used in combination with other markers to increase diagnostic accuracy.
