Nottingham Histologic score - Histology

What is the Nottingham Histologic Score?

The Nottingham Histologic Score, also known as the Nottingham Grading System or Elston-Ellis modification of the Scarff-Bloom-Richardson grading system, is a widely used method for assessing the histological grade of breast cancer. This score helps to evaluate the aggressiveness of the tumor by examining three specific histological features.

What Are the Components of the Nottingham Histologic Score?

The score is based on the evaluation of three components:

Tubule Formation: This assesses the percentage of the tumor that forms glandular or tubular structures.
Nuclear Pleomorphism: This evaluates the variability in the size, shape, and appearance of the nuclei of the tumor cells.
Mitotic Count: This measures the number of mitotic figures, or cells that are currently dividing, in a specified area of the tissue.

How is Each Component Scored?

Each of the three components is scored on a scale from 1 to 3:

Tubule Formation:

1 point: >75% tubule formation
2 points: 10-75% tubule formation
3 points:

Relevant Publications

Clinico-Genomics Model to Predict Survival in Non-Metastatic Breast Cancer: Comparing the Performance of Machine Learning Models.

Issue Release: 2023

Computational portraits of the tumoral microenvironment in human breast cancer.

Issue Release: 2022

Prognostic and predictive parameters in breast pathology: a pathologist\'s primer.

Issue Release: 2020

Diffusion-weighted MRI characteristics associated with prognostic pathological factors and recurrence risk in invasive ER+/HER2- breast cancers.

Issue Release: 2017

Relationship of histologic grade and histologic subtype with oncotype Dx recurrence score; retrospective review of 863 breast cancer oncotype Dx results.

Issue Release: 2017

Tumor-infiltrating lymphocytes are significantly associated with better overall survival and disease-free survival in triple-negative but not estrogen receptor-positive breast cancers.

Issue Release: 2017

Stromal PD-L1 Expression Is Associated With Better Disease-Free Survival in Triple-Negative Breast Cancer.

Issue Release: 2016

Broadband optical mammography: chromophore concentration and hemoglobin saturation contrast in breast cancer.

Issue Release: 2015

Using proliferative markers and Oncotype DX in therapeutic decision-making for breast cancer: the B.C. experience.

Issue Release: 2015

Stacked Sparse Autoencoder (SSAE) for Nuclei Detection on Breast Cancer Histopathology Images.

Issue Release: 2015

A Case of Male Breast Cancer with a BRCA Gene Mutation.

Issue Release: 2015

Mitotic counts in breast cancer after neoadjuvant systemic chemotherapy and development of metastatic disease.

Issue Release: 2013

Nottingham-defined mitotic score: comparison with visual and image cytometric phosphohistone H3 labeling indices and correlation with Oncotype DX recurrence score.

Issue Release: 2013

EZH2 expression in invasive lobular carcinoma of the breast.

Issue Release: 2013

Routine pathologic parameters can predict Oncotype DX recurrence scores in subsets of ER positive patients: who does not always need testing?

Issue Release: 2011

Oncocytic carcinoma of the parotid gland: case report and review of the literature.

Issue Release: 2011

Poor prognostic significance of unamplified chromosome 17 polysomy in invasive breast carcinoma.

Issue Release: 2009

Molecular changes in primary breast tumors and the Nottingham Histologic Score.

Issue Release: 2009

Interobserver agreement and reproducibility in classification of invasive breast carcinoma: an NCI breast cancer family registry study.

Issue Release: 2006

Invasive lobular carcinoma: to grade or not to grade.

Issue Release: 2005

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