Lag 3 - Histology

What is Lag 3?

Lag 3, or Lymphocyte Activation Gene-3, is a protein encoded by the LAG3 gene. This protein functions as a negative regulatory molecule in immune responses. It shares structural similarities with the CD4 molecule and binds to MHC class II molecules.

Role in Immune Regulation

Lag 3 is expressed on activated T cells, natural killer (NK) cells, and dendritic cells. It plays a crucial role in maintaining immune homeostasis by downregulating T cell activation and proliferation. This inhibitory function helps in preventing autoimmunity and maintaining tolerance.

Lag 3 in Histological Studies

In histological studies, Lag 3 can be detected using immunohistochemistry. The presence of Lag 3-positive cells can indicate an ongoing immune response or chronic inflammation. These studies are essential for understanding the histopathological context of various diseases, including cancer and autoimmune disorders.

Clinical Significance

Lag 3 has been implicated in various clinical conditions. In cancer, high expression of Lag 3 on tumor-infiltrating lymphocytes (TILs) is often associated with poor prognosis. Similarly, in autoimmune diseases like rheumatoid arthritis, Lag 3 expression might indicate disease severity and progression.

Therapeutic Potential

Given its role in immune regulation, Lag 3 is a potential target for immunotherapy. Blocking Lag 3 can enhance T cell responses against tumors, making it a promising strategy in cancer immunotherapy. Several clinical trials are underway to evaluate the efficacy of Lag 3 inhibitors in combination with other immune checkpoint inhibitors.

Research and Future Directions

Ongoing research aims to elucidate the detailed mechanisms of Lag 3 in immune regulation and its potential as a biomarker for disease diagnosis and prognosis. Understanding how Lag 3 interacts with other immune checkpoints could pave the way for novel therapeutic interventions in various immune-related diseases.

Relevant Publications

Estimating the heat-related mortality and morbidity burden in the province of Quebec, Canada.

Issue Release: 2024

Association of longitudinal pet ownership with wheezing in 3-year-old children using the distributed lag model: the Japan Environment and Children\'s Study.

Issue Release: 2024

2D model of groundwater flow and total dissolved HCH transport through the Gállego alluvial aquifer downstream the Sardas landfill (Huesca, Spain).

Issue Release: 2024

Expression and Prognostic Significance of LAG-3, TIGIT, VISTA, and IDO1 in Endometrial Serous Carcinoma.

Issue Release: 2024

Causal association between environmental variables and the excess cases of cutaneous leishmaniasis in Colombia: are we looking to the wrong side?

Issue Release: 2024

Therapeutic potential of co-signaling receptor modulation in hepatitis B.

Issue Release: 2024

Intertrochanteric femoral fracture with lateral wall fracture at the lag screw insertion site may cause postoperative anterior wall fracture and lead to deterioration in activities of daily living.

Issue Release: 2024

Advances in immunotherapy for breast cancer and feline mammary carcinoma: From molecular basis to novel therapeutic targets.

Issue Release: 2024

Syndromic Surveillance Tracks COVID-19 Cases in University and County Settings: Retrospective Observational Study.

Issue Release: 2024

Overexpression of LAG-3: a potential indicator of low immune function in tuberculosis.

Issue Release: 2024

IL-6 Inhibition as a Therapeutic Target in Aged Experimental Autoimmune Encephalomyelitis.

Issue Release: 2024

Mutual exclusivity and co-occurrence patterns of immune checkpoints indicate NKG2A relates to anti-PD-1 resistance in gastric cancer.

Issue Release: 2024

Patient Characteristics and Postoperative Outcomes of Surgically Treated Inferior Pole Patellar Sleeve Fractures.

Issue Release: 2024

Immunotherapy of Clear-Cell Renal-Cell Carcinoma.

Issue Release: 2024

Population modeling analyses of crizotinib in pediatric patients with ALK-positive advanced cancers.

Issue Release: 2024

Comparison of PD-L1, VISTA, LAG-3, and GAL-3 Expressions and Their Relationships to Mismatch Repair Protein and p53 Expression in 529 Cases of Endometrial Carcinoma.

Issue Release: 2024

Eyelid retraction during smiling in a patient with monocular congenital ptosis: a case report.

Issue Release: 2024

What is the Optimal Nail Length to Treat Osteoporotic Subtrochanteric Fractures? A Finite Element Analysis.

Issue Release: 2024

Early effect of onabotulinumtoxinA on EEG-based functional connectivity in patients with chronic migraine: A pilot study.

Issue Release: 2024

Impact of SARS-CoV-2 vaccines on Covid-19 incidence and mortality in the United States.

Issue Release: 2024

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