Fluorescein Angiography - Histology

What is Fluorescein Angiography?

Fluorescein angiography is a diagnostic procedure that uses a special dye called fluorescein and a camera to examine blood flow in the retina and choroid. In the context of histology, it is particularly useful for studying the vascular structures within these tissues.

How Does Fluorescein Angiography Work?

The process begins with the intravenous injection of fluorescein dye. As the dye circulates through the bloodstream, it eventually reaches the eyes. The dye fluoresces when exposed to a specific wavelength of light, allowing for the visualization of blood vessels. A specialized camera captures images of the dye as it travels through the retinal and choroidal vasculature.

Applications in Histology

In histology, fluorescein angiography is used to study the microvasculature of tissues. This is particularly important in the examination of diseases that affect blood vessels, such as diabetic retinopathy and age-related macular degeneration. By analyzing the images obtained, histologists can assess the integrity and functionality of blood vessels, identify areas of leakage, and observe abnormal vascular growth.

Advantages and Limitations

The primary advantage of fluorescein angiography is its ability to provide detailed images of blood vessels in real time. This is invaluable for diagnosing and monitoring various vascular diseases. However, the procedure does have limitations. For instance, it cannot provide information about deeper structures beyond the reach of the dye. Additionally, there can be side effects associated with the dye, such as allergic reactions.

What Are the Alternatives?

Several alternatives to fluorescein angiography exist, including indocyanine green angiography and optical coherence tomography angiography (OCTA). Indocyanine green angiography uses a different dye that can provide better visualization of deeper vascular structures. OCTA, on the other hand, uses light waves to capture detailed images of blood flow without the need for dye injection.

Future Directions

Advancements in imaging technologies continue to improve the capabilities of fluorescein angiography. For example, the integration of artificial intelligence and machine learning algorithms can enhance image analysis, allowing for more accurate and rapid diagnoses. Additionally, the development of non-invasive techniques may eventually replace the need for dye injections, reducing the risk of side effects.

Relevant Publications

In Vivo Imaging of Rodent Retina in Retinal Disease.

Issue Release: 2025

Pre-Clinical Studies of a Novel Bispecific Fusion Protein Targeting C3b and VEGF in Neovascular and Nonexudative AMD Models.

Issue Release: 2024

Protocol for performing deep learning-based fundus fluorescein angiography image analysis with classification and segmentation tasks.

Issue Release: 2024

Fluorescein Angiography of Dark without Pressure.

Issue Release: 2024

Fatal Outcome Due to Kounis Syndrome Following Fluorescein Retinal Angiography: A Case Report.

Issue Release: 2024

miR-199a-5p modulates choroidal neovascularization by regulating Wnt7b/Wnt/β-catenin signaling pathway.

Issue Release: 2024

Central retinal artery occlusion after intravitreal brolucizumab injection for treatment-naïve neovascular age-related macular degeneration; a case report.

Issue Release: 2024

Study protocol: optical coherence tomography angiography for the detection of neovascular age-related macular degeneration: a comprehensive multicentre diagnostic accuracy study in the UK-the ATHENA study.

Issue Release: 2024

A case report of pediatric-onset MS associated uveitis.

Issue Release: 2024

Genetic context modulates aging and degeneration in the murine retina.

Issue Release: 2024

UWAFA-GAN: Ultra-Wide-Angle Fluorescein Angiography Transformation via Multi-scale Generation and Registration Enhancement.

Issue Release: 2024

Improved accuracy of spectral-domain optical coherence tomography and optical coherence tomography angiography for monitoring myopic macular neovascularisation activity.

Issue Release: 2024

Deep learning segmentation of non-perfusion area from color fundus images and AI-generated fluorescein angiography.

Issue Release: 2024

Ultra-wide field indocyanine green angiography in central serous chorioretinopathy.

Issue Release: 2024

Clinical Implications of Alternating Hypointense Bands on OCT-Angiography in Retinal Vascular Occlusive Disease.

Issue Release: 2024

Effects of slit lamp-delivered retinal laser photobiomodulation in a rat model of choroidal neovascularization.

Issue Release: 2024

Improvement in Central Serous Chorioretinopathy Following Multiwavelength Photobiomodulation Treatment - Case Report.

Issue Release: 2024

Optical coherence tomography angiography macular biomarkers of peripheral retinal ischemia in diabetic macular edema: secondary endpoints from the clinical study \"FOVEA\".

Issue Release: 2024

Optical coherence tomography angiography in pediatric ocular cutis marmorata telangiectatica congenita: A case series.

Issue Release: 2024

Occult retinal neovascularization following intravitreal bevacizumab and laser treatment for retinopathy of prematurity.

Issue Release: 2024

What are Some Common Disorders Related to Ectodermal Development?

How can Google Forms be Utilized for Histology Assessments?

How are Carbohydrate Chains Synthesized?

How Should Containers Be Sealed?

What Role Does DIT Play in Thyroid Hormone Biosynthesis?

What Defines Similarity in Histology?

How Does SEM Work?

How Are Metabolic Enzymes Studied in Histology?

How to Ensure Sample Integrity Over Time?

How to Interpret LDH Assay Results?

Partnered Content Networks

Relevant Topics