Emerin - Histology

What is Emerin?

Emerin is a protein that is integral to the inner nuclear membrane. It is encoded by the EMD gene located on the X chromosome. Emerin is a member of the nuclear envelope protein family and is involved in maintaining the structure and function of the nuclear envelope.

Role of Emerin in the Cell

Emerin plays a crucial role in the structural organization of the nucleus. It helps in anchoring the nuclear membrane to the nuclear lamina—a dense fibrillar network inside the nucleus. This anchoring is vital for the mechanical stability of the nucleus, especially during cell division and in response to mechanical stress.

Histological Localization

In histological studies, emerin is typically localized to the inner nuclear membrane. Immunohistochemistry and immunofluorescence techniques are commonly used to visualize emerin. These methods use antibodies specific to emerin, allowing researchers to observe its distribution within cells. Under a microscope, emerin appears as a distinct rim around the nucleus, highlighting its association with the nuclear envelope.

Pathological Implications

Mutations in the EMD gene can lead to a range of genetic disorders, most notably Emery-Dreifuss Muscular Dystrophy (EDMD). EDMD is characterized by progressive muscle weakness, joint contractures, and cardiac issues. The absence or malfunction of emerin disrupts the integrity of the nuclear envelope, making cells more susceptible to mechanical stress.

Research and Diagnostic Applications

The study of emerin is not only important for understanding basic cellular functions but also for diagnostic purposes. The detection of emerin deficiency can aid in the diagnosis of EDMD and other related disorders. Researchers are also exploring the role of emerin in cell signaling and its potential involvement in other diseases such as cancer.

Future Perspectives

Advancements in histological techniques continue to enhance our understanding of emerin's functions and its role in disease. Future research may uncover new therapeutic targets for conditions associated with emerin deficiency. Additionally, the development of gene therapy and other molecular approaches holds promise for treating genetic disorders linked to emerin.

Relevant Publications

Developmental changes in nuclear lamina components during germ cell differentiation.

Issue Release: 2024

Emerin mislocalization during chromatin bridge resolution can drive prostate cancer cell invasiveness in a collagen-rich microenvironment.

Issue Release: 2024

Effect of lamins and emerin on nuclear morphology and histological architecture in lung adenocarcinoma.

Issue Release: 2024

Emerin deficiency drives MCF7 cells to an invasive phenotype.

Issue Release: 2024

Natural History of Dilated Cardiomyopathy Due to in Emerin Protein.

Issue Release: 2024

Altered expression and localization of nuclear envelope proteins in a prostate cancer cell system.

Issue Release: 2024

N-terminal tags impair the ability of Lamin A to provide structural support to the nucleus.

Issue Release: 2024

N-terminal tags impair the ability of Lamin A to provide structural support to the nucleus.

Issue Release: 2024

Emerin deficiency drives MCF7 cells to an invasive phenotype.

Issue Release: 2024

FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity.

Issue Release: 2024

Reconstitution of nuclear envelope subdomain formation on mitotic chromosomes in semi-intact cells.

Issue Release: 2024

Characteristics of nuclear architectural abnormalities of myotubes differentiated from Lmna skeletal muscle cells.

Issue Release: 2024

Role of Emerin in regulating fibroblast differentiation and migration at the substrate of stiffness coupled topology.

Issue Release: 2024

Proteomic characterization of human LMNA-related congenital muscular dystrophy muscle cells.

Issue Release: 2024

Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.

Issue Release: 2024

Identification of the proteolytic signature in CVB3-infected cells.

Issue Release: 2024

Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis.

Issue Release: 2024

Analysis of the GFP-labelled β-dystroglycan interactome in HEK-293 transfected cells reveals novel intracellular networks.

Issue Release: 2024

The expression and role of the Lem-D proteins Ankle2, Emerin, Lemd2, and TMPO in triple-negative breast cancer cell growth.

Issue Release: 2024

Nanotube patterning reduces macrophage inflammatory response via nuclear mechanotransduction.

Issue Release: 2023

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