CD41 - Histology

What is CD41?

CD41, also known as Glycoprotein IIb (GPIIb), is a protein found on the surface of platelets and certain other cells. It plays a crucial role in platelet aggregation and is essential for normal clotting. CD41 is a part of the integrin αIIbβ3 complex, which is vital for cell adhesion and signal transduction.

Where is CD41 Expressed?

CD41 is primarily expressed on the surface of platelets and megakaryocytes, the precursor cells that give rise to platelets. Additionally, CD41 can be found on certain subsets of hematopoietic stem cells and progenitor cells, making it a valuable marker for identifying and studying these cells.

What is the Function of CD41?

The primary function of CD41 is to mediate platelet aggregation, which is essential for the formation of a hemostatic plug during blood clotting. CD41, in conjunction with CD61 (β3 integrin), forms the αIIbβ3 integrin complex that binds to fibrinogen and other adhesive proteins, facilitating platelet-platelet interactions.

How is CD41 Used in Histology?

In histology, CD41 is commonly used as a cell marker to identify and study platelets, megakaryocytes, and certain hematopoietic cells. Immunohistochemistry (IHC) techniques employing anti-CD41 antibodies are widely utilized to visualize these cells in tissue sections. This is particularly important in the diagnosis and research of hematologic disorders and in stem cell research.

What are the Clinical Implications of CD41?

Alterations in CD41 expression or function can have significant clinical implications. For instance, mutations in the gene encoding CD41 (ITGA2B) can lead to Glanzmann thrombasthenia, a rare bleeding disorder characterized by defective platelet aggregation. Additionally, CD41 is used as a marker in the diagnosis of certain leukemias and other hematological malignancies.

Research and Future Directions

Ongoing research is exploring the roles of CD41 in various biological processes beyond hemostasis, including its involvement in stem cell regulation and immune response. Advances in understanding CD41 signaling pathways and interactions could provide new insights into disease mechanisms and potential therapeutic targets.

Relevant Publications

G2 arrest primes hematopoietic stem cells for megakaryopoiesis.

Issue Release: 2024

Off-target effect of high-dose sildenafil on adenosine 5\'- diphosphate and collagen-induced platelet activation through mitogen-activated protein kinase pathway in treated BALB/C mice and in vitro experiments: A preliminary study.

Issue Release: 2024

SDF-1 promotes metastasis of NSCLC by enhancing chemoattraction of megakaryocytes through the PI3K/Akt signaling pathway.

Issue Release: 2024

Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia.

Issue Release: 2024

Atherothrombotic Risk Factors in Patients With Rheumatoid Arthritis.

Issue Release: 2024

Spatiotemporal expression profiles of c-Mpl mRNA in the tooth germ: comparative expression dynamics of vascularization-related genes.

Issue Release: 2024

A novel therapy for fracture healing by increasing lymphatic drainage.

Issue Release: 2024

Platelet derived exosomes disrupt endothelial cell monolayer integrity and enhance vascular inflammation in dengue patients.

Issue Release: 2024

Evaluation of artificial intelligence-assisted morphological analysis for platelet count estimation.

Issue Release: 2024

The involvement of krüppel-like transcription factor 2 in megakaryocytic differentiation induction by phorbol 12-myrestrat 13-acetate.

Issue Release: 2024

A Novel Engineering Cell Therapy Platform Mimicking the Immune Thrombocytopenia-Derived Platelets to Inhibit Cytokine Storm in Hemophagocytic Lymphohistiocytosis.

Issue Release: 2024

[Platelet-specific knockout inhibits platelet production and activation and reduces thrombosis in mice].

Issue Release: 2024

Genetic Profile of Beta-Thalassemia and Sickle Cell Disease in Eastern Uttar Pradesh.

Issue Release: 2024

Effects of Platelet-Rich Plasma-Derived Exosomes on Proliferation and Migration of Tendon Stem/Progenitor Cell.

Issue Release: 2024

Genotype analysis of 55,281 cases of thalassemia in northern Guangxi.

Issue Release: 2024

Platelet Proteome Reveals Novel Targets for Hypercoagulation in Pseudoexfoliation Syndrome.

Issue Release: 2024

A New δ-Globin Gene Variant: Hb A2-Yulin [δ46(CD5)Gly→Arg,: C.139G > A].

Issue Release: 2024

Xuefu Zhuyu Decoction alleviates deep vein thrombosis through inhibiting the activation of platelets and neutrophils via sirtuin 1/nuclear factor kappa-B pathway.

Issue Release: 2024

SNPscan Combined With CNVplex as a High-Performance Diagnostic Method for Thalassemia.

Issue Release: 2024

Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis.

Issue Release: 2024

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