Different tissues exhibit varying levels of exposure to DNA-damaging agents. For example, skin tissues are frequently exposed to UV radiation, while lung tissues may be subjected to harmful pollutants. In such scenarios, an efficient NHEJ mechanism is crucial for repairing the frequent DNA double-strand breaks, thus preventing mutations and maintaining tissue health. In immune tissues, NHEJ plays a vital role in V(D)J recombination, a process essential for the development of [lymphocytes]().
