The architecture of follicles is crucial for their function. Any disruption or alteration in this architecture can lead to various diseases. For example, in the thyroid gland, a change in follicular architecture can indicate conditions like [thyroiditis](https://en.wikipedia.org/wiki/Thyroiditis) or thyroid cancer. In the lymphoid tissue, altered follicular architecture can be a sign of lymphoma. Understanding the normal and pathological architecture of follicles helps in diagnosing and treating these conditions.
