What Role do T Follicular Helper (Tfh) Cells Play?
Tfh cells are essential for the germinal center reaction. They provide critical help to B cells through cell-cell interactions and the secretion of cytokines like IL-21. Tfh cells express surface molecules such as CD40L, which interacts with CD40 on B cells, promoting their survival, proliferation, and differentiation. Without Tfh cells, the formation and function of germinal centers would be severely impaired.
