Abnormalities in proteoglycan metabolism can lead to various diseases:
Osteoarthritis: Degradation of aggrecan in cartilage can contribute to the development of osteoarthritis. Ehlers-Danlos Syndrome: Mutations affecting proteoglycans can result in connective tissue disorders like Ehlers-Danlos syndrome. Cancer: Altered expression of proteoglycans can influence tumor growth and metastasis.
