What is the Role of DNMT Inhibitors in Cancer Treatment?
Cancer cells often exhibit abnormal DNA methylation patterns, including hypermethylation of promoter regions of tumor suppressor genes and global hypomethylation, which can contribute to genomic instability. DNMT inhibitors can reverse these abnormal methylation patterns, restoring normal gene function and inhibiting cancer cell growth. Histological studies of cancer tissues before and after treatment with DNMT inhibitors can reveal changes in cellular morphology, apoptosis, and differentiation.
