What is the Histological Impact of GALT Deficiency?
Deficiency in GALT activity leads to a condition known as classic galactosemia. Histologically, this can result in several abnormalities: - Liver: Hepatocytes may exhibit signs of fatty change (steatosis), fibrosis, and in severe cases, cirrhosis. - Kidneys: Histological examination may reveal renal tubular damage and accumulation of galactose-related metabolites. - Brain: Neuropathological changes can include gliosis, atrophy, and in some cases, cerebral edema.
