What is the Clinical Significance of the Brush Border?
The integrity of the brush border is crucial for normal physiological functions. Damage to the brush border can lead to malabsorption syndromes and kidney dysfunction. For example, a condition known as celiac disease involves the destruction of the brush border in the small intestine, leading to nutrient malabsorption. Similarly, acute tubular necrosis can damage the brush border in the kidneys, impairing renal function.
