PSEN1, or Presenilin 1, is a gene that encodes a protein involved in the cleavage of integral membrane proteins, a process crucial in many cellular functions. This protein is a part of the gamma-secretase complex, which plays a significant role in the proteolytic processing of various proteins, including the amyloid precursor protein (APP). Mutations in PSEN1 are largely associated with early-onset Alzheimer's disease.
