What is Phosphoenolpyruvate Carboxykinase (PEPCK)?
Phosphoenolpyruvate carboxykinase (PEPCK) is an essential enzyme involved in the process of gluconeogenesis, the metabolic pathway that results in the generation of glucose from non-carbohydrate substrates. This enzyme catalyzes the conversion of oxaloacetate into phosphoenolpyruvate and carbon dioxide. PEPCK exists in two isoforms: a cytosolic form (PEPCK-C) and a mitochondrial form (PEPCK-M), each encoded by different genes.
