Hemophagocytosis refers to the engulfment and digestion of blood cells by macrophages, which are a type of immune cell. This process is often observed in conditions such as Hemophagocytic Lymphohistiocytosis (HLH), a severe systemic inflammatory syndrome. Macrophages, which are derived from monocytes, play a crucial role in the immune system by phagocytosing dead cells, cellular debris, and pathogens.