What Histological Techniques are Used to Study rRNA Transcription?
Various histological techniques are used to study rRNA transcription. These include:
- Silver Staining: Highlights nucleolar organizer regions (NORs) which are associated with active rRNA gene transcription. - Immunohistochemistry: Detects specific proteins involved in rRNA transcription, such as RNA polymerase I and nucleolar proteins like fibrillarin. - In Situ Hybridization: Uses labeled probes to detect rRNA transcripts within tissue sections, providing spatial information about gene activity.