What Histological Changes are Observed in Myophosphorylase Deficiency?
Histological examination of muscle tissues from patients with myophosphorylase deficiency typically reveals the absence or significantly reduced staining for the enzyme. Additionally, there may be an accumulation of glycogen within the muscle fibers, which can be visualized using periodic acid-Schiff (PAS) staining. This accumulation is due to the inability of the muscle cells to break down glycogen effectively.
